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Denali Therapeutics Inc.

DNLINASDAQHealthcare·US · USD
$25.89
+0.32 (+1.25%)
Close · 2026-06-29

Price

Key statistics

Valuation
Market cap4.11B USD
Enterprise value3.11B USD
Trailing P/E-8.72
Forward P/E-10.32
PEG ratio0.76
Price / sales0.00
Price / book4.38
Profitability
Gross margin0.00%
Operating margin0.00%
Profit margin0.00%
Return on assets-26.95%
Return on equity-49.59%
Income (TTM)
Revenue0.00 USD
Gross profit-406.40M USD
EBITDA-531.76M USD
Net income-508.02M USD
Diluted EPS-$2.88
Rev. growth (YoY)0.00%
Balance sheet
Total cash987.68M USD
Total debt40.05M USD
Debt / equity4.32
Current ratio9.29
Book value / share$5.84
Cash flow (TTM)
Operating cash flow-412.34M USD
Levered free cash flow-190.33M USD
Shares & price
Shares outstanding158.66M
Float144.23M
Held by institutions99.91%
Beta1.01
50-day MA$20.48
200-day MA$18.61
52-week high$26.19
52-week low$12.58
Dividends
Forward rate
$0.00
Yield
0.00%
Payout ratio
0.00%
Frequency
Unknown
Earnings (EPS)
DateEst.ActualSurprise2026-05-07-0.71-0.69+2.82%2026-03-27-3.78-0.97+74.34%2026-02-26-0.75-0.73+2.67%2025-11-06-0.76-0.74+2.63%2025-08-11-0.74-0.72+2.70%
About Denali Therapeutics Inc.

Denali Therapeutics Inc. is a biopharmaceutical company focused on discovering and developing therapeutics to address neurodegenerative and lysosomal storage diseases. The company engineers product candidates using proprietary technologies such as Antibody Transport Vehicle (ATV) and Enzyme Transport Vehicle (ETV) to enable effective delivery across the blood-brain barrier, targeting challenging central nervous system disorders. Its pipeline includes programs like DNL310 (Tividenofusp alfa) for Hunter syndrome (MPS II), DNL126 for MPS IIIA (Sanfilippo Syndrome A), DNL343 (eIF2B activator) for amyotrophic lateral sclerosis, BIIB122/DNL151 (LRRK2 inhibitor) for Parkinson's disease, Eclitasertib (DNL758, RIPK1 inhibitor) for peripheral inflammatory diseases, and others such as TAK-594/DNL593 for frontotemporal dementia-granulin and initiatives targeting TREM2 and Tau. Denali Therapeutics Inc. advances these candidates through clinical development, emphasizing innovative solutions for unmet needs in neurology and rare genetic disorders. Founded in 2013 and headquartered in South San Francisco, California, it plays a key role in the biotechnology sector dedicated to neurodegeneration.

Sector
Healthcare
Industry
Biotechnology
CEO
Dr. Ryan J. Watts Ph.D.
Employees
517
Headquarters
South San Francisco, CA, United States

Frequently asked questions about Denali Therapeutics Inc.